The Food and Drug Administration (FDA) is recommending banning a compound found in unregulated tablets, gummies and drink mixes sold online and at gas stations and convenience stores, the Trump ...

The FDA recently proposed scheduling synthetic and concentrated forms of 7-hydroxymitragynine, or 7-OH, under the Controlled ...

Positive allosteric modulators (PAMs) of the mu-opioid receptor (MOR) have been hypothesized as potentially safer analgesics than traditional opioid drugs. This is based on the idea that PAMs will ...

“A partial mu-opioid receptor agonist, buprenorphine may insufficiently mitigate opioid cravings and precipitate withdrawal in patients who use fentanyl, which is 50 to 100 times more potent ...

Women with anorexia had higher levels of mu-opioid receptor availability in key areas of the brain involved in reward processing, such as the caudate, putamen, and nucleus accumbens.

Product: Nucynta Company: PriCara Pharmacologic class: Opioid Active ingredient: Tapentadol 50 mg, 75 mg, 100 mg tabs. Indication: Moderate-to-severe acute pain in patients > 18 years of age.

The Canadian-based psychedelics company Nirvana Life Sciences Inc. filed a patent for the deuterated form of 7-hydroxymitragynine (D7-h.), commonly known as Kratom. Nirvana focuses on developing ...

NKTR-181 is a long-acting selective full mu-opioid agonist; it is not a prodrug or a reformulation of an existing opioid. This novel agent has low permeability across the blood-brain barrier ...

In the second part of the study, Wang et al. deployed an entire armada of experimental approaches in mammals to investigate the activity of GPR139 against the mu opioid receptor at both the ...

Positive Topline Results for First-in-Class Opioid Nektar's NKTR-181 is the first full mu-opioid agonist molecule designed to provide potent pain relief without the high levels of euphoria that ...