The molecular architecture of LPD-3 and putative lipid-transfer features. Credit: Nature (2025). DOI: 10.1038/s41586-025-08918-y Cryo-EM density map of the full-length LPD-3 complex.

More information: Anna M. Kotowska et al, Study on molecular orientation and stratification in RNA-lipid nanoparticles by cryogenic orbitrap secondary ion mass spectrometry, Communications ...

Scientists have developed a method for analysing the structure of lipid nanoparticles that could be used to improve vaccine and drug delivery, targeting a wide range of health issues.

Lipid nanoparticles (LNP’s) came to prominence for delivery of RNA with the success of the Moderna and Pfizer BioNTech COVID-19 vaccines. They are also used to deliver therapeutic treatments including ...