Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several ...

Multivariate analysis of expression of the microtubule-associated protein, tau, predicts improved progression free and overall survival in patients with metastatic HER-2-negative breast cancers ...

Using a novel quantitative chemoproteomic strategy, the team uncovered a protective role of dopamine (DA) in regulating the function of the microtubule-associated protein Tau.

Hyperphosphorylation of microtubule-associated protein tau is a major driver in the pathogenesis of a variety of neurodegenerative diseases, including Alzheimer’s disease (AD) and other tauopathies.

Biogen Inc. has reported promising data from a phase 1b trial of BIIB080, an investigational antisense oligonucleotide therapy that reduced soluble tau protein in cerebrospinal fluid in patients ...

About BIIB080BIIB080 is an investigational antisense oligonucleotide (ASO) therapy designed to target microtubule-associated protein tau (MAPT) mRNA to reduce the production of tau protein ...

Background: Microtubule associated proteins (MAPs) endogenously regulate microtubule stability, have been reported as prognostic markers, and may predict response to taxane therapy. Previous work in ...

Tau-regulating protein identified as a promising target for developing Alzheimer's disease treatment Date: July 27, 2023 Source: University of Pennsylvania School of Medicine ...

BIIB080 is an investigational antisense oligonucleotide (ASO) therapy designed to target microtubule-associated protein tau (MAPT) mRNA to reduce the production of tau protein. Abnormal ...