in regulating the function of the microtubule-associated protein Tau. This discovery deepens our understanding of dopamine's physiological and pathological roles in the human brain. The research ...

Tau is a microtubule-associated protein that helps to stabilize the structure of neurons, specifically by supporting microtubules, cylindrical structures that contribute to cell motility ...

Tau hyperphosphorylation contributes to microtubule destabilization ... These kinases are also associated with β-amyloid precursor protein (APP) processing and β-amyloid-induced neurotoxicity.

BIIB080 is an investigational antisense oligonucleotide therapy that targets microtubule-associated protein tau mRNA preventing the production of the disease-causing protein. The Fast Track ...

Researchers investigate tauopathy mechanisms and turn to tau detection methods to help improve health care outcomes and lower the economic burden of these diseases. The microtubule-associated protein ...

Researchers from Eli Lilly & Co. reported preclinical data on LY-3954068, a MAPT small-interference RNA (siRNA) strategy in AD models. The therapy is designed to reduce tau protein synthesis by ...