Tau is a microbutule-associated protein that can form pathological aggregates in neurodegenerative conditions such as Alzheimer's disease. Tau can undergo acetylation at lysine residues within its ...

Tau protein is essential for microtubule stability and neuronal function. The protein’s disfunction is linked to several ...

Tau protein aggregates are present in a group of disorders, collectively termed the tauopathies. Alzheimer's disease is the most common of those disorders, while frontotemporal dementia is most ...

Modification Details PS19 transgenic mice express mutant human microtubule-associated protein tau, MAPT, driven by the mouse prion protein (Prnp) promoter. The transgene encodes the disease-associated ...

Conclusion High Tau protein expression is associated with better prognosis in patients treated with adjuvant anthracycline and paclitaxel chemotherapy and endocrine therapy, but there was no ...

While dopamine's role in the nervous system is well-known, its functional impact on protein modifications, particularly Tau, has remained poorly understood.

Understanding healthy function of tau, protein associated with dementia Date: August 25, 2022 Source: University of California - Davis Summary: In Alzheimer's Disease and other neurodegenerative ...

Tau protein is a microtubule-associated protein (MAP) encoded by the MAPT gene. 1 Tau is primarily localized in axons, where it binds, compresses, and stabilizes polymerized microtubules. 1-3 ...

BIIB080 is an antisense oligonucleotide therapy designed to target microtubule-associated protein tau mRNA and reduce the production of tau.

Tau proteins are produced through alternative splicing of a single gene called MAPT (microtubule-associated protein tau).

Clumps and tangles of tau protein are associated with Alzheimer's disease and other dementias, but tau protein also plays a role in healthy nerve cells. Healthy tau can assemble into an envelope ...