In the E-Class, the 2022 E450 4Matic's 23/30/25 mpg city/highway/combined compares well to the 2022 E350 with AWD (21/29/24 mpg) and 2022 E350 with RWD (23/31/26)—2021 EPA numbers differ slightly.

With so many options on the Mercedes E-Class, how do you choose the best ones? Here are our five favorite features, after living with a 2021 E450.

A quick perusal of Mercedes-Benz's own sales numbers don't paint a rosy picture for its compact sedan, with the A-Class' Q3 2021 sales down by 75.3% year over year and Q4 2021 sales down by 65.9% ...