For the first time, scientific collaborators at the UNC School of Medicine, UC-San Francisco, and the University of Buffalo created molecules to selectively bind to MT1 melatonin receptors on the ...

"For us, it was at first exciting to see the novelty of the new ligands that emerged from fitting members of an ultra-large chemical library into the receptor structure,” said Shoichet. “That's what ...

Researchers have discovered through a vast and novel computational library the first molecules that can modulate circadian rhythms by binding with high selectivity to the MT1 melatonin receptor in ...

Melatonin is a hormone produced in the pineal gland. Interestingly, the pineal gland is a tiny structure in the center of the brain that was described by René Descartes, a French philosopher, ...

The discovery that these molecules (UCSF 7447 and UCSF 3384) that never existed before, attach with high strength and selectivity to human or mouse MT1 melatonin receptors.

The new research caps what Dubocovich says has been her 15-year search to discover MT1 ligands. “Ever since we demonstrated that melatonin’s effect of resetting biological clocks in vivo circadian ...

The researchers showed that both melatonin receptors contain narrow channels embedded in the cell's fatty membranes. These channels only allow melatonin, which can exist happily in both water and ...

Melatonin articles from across Nature Portfolio. Atom; RSS Feed; Definition. Melatonin is an endocrine hormone with a monoamine alkaloid structure, produced from the amino acid tryptophan.

Computational protein structure prediction tools were used to analyze a library of synthetic receptors, revealing that ...

Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways. Progress in Neurobiology, 85 , 335-353. More references ...

Melatonin is a key endogenous hormone that regulates circadian rhythms, sleep-wake cycles, and numerous physiological functions, including antioxidative defense and metabolic regulation.

Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways. Progress in Neurobiology, 85 , 335-353. More references ...