Mast cell activation syndrome (MCAS) is a condition where the mast cells are inappropriately triggered. Primary MCAS is due to a mutation in the mast cells themselves (typically in the KIT gene ...

A new way of treating common inflammatory skin conditions such as eczema is on the horizon, according to a new study. American researchers discovered that a compound called SYM2081 inhibited ...

Mast cell activation syndrome (MCAS) is a condition where the mast cells are inappropriately triggered. Primary MCAS is due to a mutation in the mast cells themselves (typically in the KIT gene ...

Mast cell activation disorder (MCAD), also known as mastocytosis, is a rare condition caused by an excess number of mast cells in the body's tissues.

A recent study published in Science Translational Medicine has examined a new approach to address inflammatory skin diseases, such as dermatitis and rosacea, by focusing on a specific glutamate ...

Stress Mediators & Mast Cell Activation In the skin, mast cells are predominantly localized to the upper dermis and close to blood vessels, skin appendages and neurons (Figure 1). Cutaneous mast ...

The API failed to deliver the resource. Dr. Jim Harris from South Bend Clinic and one of his patients, Michelle Rannells, joined us on 16 News Now at Noon to talk about mast cell disease.

An exhaustive resource about MCAS is Lawrence Afrin MD’s 2016 book, Never Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemic of Chronic Illness and Medical Complexity.

Human mast cells were enzymatically dispersed from tonsil and skin tissues. The dispersed cells were then cultured with various stimuli, and tryptase and histamine levels in cell supernatants ...

Figure 1. Stress and skin mast cell activation. A hypothetical model is shown for the activation of the central and local hypothalamic–pituitary–adrenal (CRH, ACTH, α-melanocyte-stimulating ...