Nature

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy

Figure 1: A unique subtype of melanoma expresses MHC-II. Figure 2: Characterization of MHC-II(+) melanoma cell lines. Figure 3: MHC-II-positive melanoma cell lines associate with NRAS mutations. We ...
ascopubs.org

LAG 3/MHC 2 and PD 1/PD L1 expression in non-small cell lung cancer patients.

Association of response to programmed death 1 receptor or ligand (PD1/PDL1) blockade with immune-related gene expression profiling across three cancer-types. This is an ASCO Meeting Abstract from the ...
Medscape

MHC-1-Opathies Linked to Ancient Retrovirus Infections

SEATTLE — The genetic vulnerability to psoriasis and related autoimmune diseases may be traceable to evolutionary pressure to resist ancient infections by retroviruses. The theory is that variations ...
ascopubs.org

ATTAC-MCC: Phase I/II study of autologous CD8+ and CD4+ transgenic T cells expressing a high affinity MCPyV-specific TCR combined with checkpoint inhibitors and class I MHC ...

Optimization of Voyager V1 (VV1) oncolytic virus systemic delivery in combination with cemiplimab and ipilimumab in patients with melanoma and non–small cell lung cancer (NSCLC). Background: Merkel ...
News Medical

Study reports SARS-CoV-2 accessory proteins downregulate MHC-I expression using distinct mechanisms

In a recent study posted to the bioRxiv* preprint server, researchers observed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) downregulates the expression of major histocompatibility ...
News Medical

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

A new study published on the preprint server bioRxiv* analyzed the mechanisms by which two SARS-CoV-2 accessory proteins, ORF3a and ORF7a, can downregulate the expression of major histocompatibility ...
JSTOR Daily

Significance of Lyt Phenotypes: Lyt2 Antibodies Block Activities of T Cells That Recognize Class 1 Major Histocompatibility Complex Antigens Regardless of Their Function

The effect of anti-Lyt2 on the generation of helper T-cell function and on cytotoxic effects specific for subregions of the major histocompatibility complex (MHC) was determined. The addition of ...