Here, we found that this phenomenon is common to many cancer types driven by EGFR, KRAS, or BRAF mutations in response to multiple, clinically approved MAPK pathway inhibitors. In 2D cultures and 3D ...

Clinical tests of the novel small-molecule inhibitor of p38α MAPK, VX-702, have resulted in an all-too-familiar outcome: modest clinical efficacy and transient inhibition of inflammatory markers.

Here we track the responses of thousands of single melanoma cells to BRAF inhibitors and show that a subset of cells escapes drug via non-genetic mechanisms within the first three days of treatment.

The most common medications to manage symptoms of stress are tranquilizers, beta-blockers, and selective serotonin reuptake inhibitors (SSRIs), among others. Additional treatments may include ...

Small molecule inhibitors restore normal BRAF structure, offering insight into cancer-causing mutations by Myreille Larouche, University of Montreal edited by Gaby Clark , reviewed by Robert Egan ...

A functional measurement of MAPK pathway activation to predict response to MEK inhibitors in RAS-mutated patients.. JCO 37 , 3071-3071 (2019). DOI: 10.1200/JCO.2019.37.15_suppl.3071 ...

Influenza and COVID-19 infections can trigger an out-of-control immune response involving molecules called cytokines. An illustration of interleukin-4, a cytokine involved in allergic response, is ...

A tiny chemical modification commonly found on messenger RNAs plays a surprisingly large role in how cells respond to stress, according to a study led by Weill Cornell Medicine investigators.