scientists could only study autophagy by examining cells with electron microscopes. Using this tool, they established that after autophagosomes form, they fuse to the lysosomal membrane to form a ...

Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National ...

The protein Spns1 helps transport fat molecules out of lysosomes, preventing harmful buildup and offering insights for rare ...

New research has made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat ...

In normal cells, phosphatidylserine (PS) and phosphatidyl-ethanolamine (PE) residues are found in the inner membrane ... of lysosomes to the autophagosome and thus inhibits the completion of the ...

Among these, the transcription factors EB (TFEB) and E3 (TFE3) caught Tan’s attention, because their activation coincided with genes that increased lysosome production. TFEB is also an ancient ...

By supplying membranes from donor sources, ATG9-mediated cycling systems, which comprise the core proteins ATG9, ATG2, VPS13D and WIPI1/2, facilitate the elongation of phagophore.

Breakthrough NUS discovery sheds light on cellular recycling mechanism and potential for treating rare diseases Singapore ...

The autophagosomes, autolysosomes and lysosomes can be considered as different stages of the cellular recycling process. Therefore, when cells notice they have too much "junk" inside, autophagy ...

[76] It is a degradative, membrane-based system by which long-lived intracellular products are removed and turned over via the lysosome. Autophagy is highly conserved; in a unicellular world ...