More information: Kangfu Peng et al, The autophagy protein ATG-9 regulates lysosome function and integrity, Journal of Cell Biology (2025). DOI: 10.1083/jcb.202411092.

Delving deeper, the researchers found that blocking autophagosome-lysosome fusion and autolysosomal degradation (the downstream steps of autophagy) abrogated 6-OHDA-induced PARK7 secretion ...

Then, after fusion with a lysosome, the inner vesicle of the autophagosome is digested along with the cargo, and the products are released into the cytoplasm. Over the past 25 years, researchers have ...

Autophagy is a natural process in which your body breaks down and cleans out damaged cells. It is triggered by fasting and has been promoted for weight loss and longevity, although there is no ...

Scientists first described autophagy in the 1960s, after discovering the cellular version of a garbage can, known as the lysosome. Parts of your cells are like parts of a car: they wear down with ...

Autophagy is the process by which cells capture large dysfunctional proteins, aging organelles, and invading pathogens in vesicles and then send them to the lysosome for degradation, said Juleen ...

The autophagy protein ATG-9 regulates lysosome function and integrity. Article Publication Date. 9-Apr-2025. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases ...

Autophagosomes eventually fuse with the lysosome mediated by STX17– ... A scheme for the autophagy machinery in mammalian cells. (IMAGE) First Hospital of Jilin University. ...

Autophagy is reduced in older skin cells.. Studies have shown that a protein called sirtuin increases autophagy. Sirtuin is increased with nutrient starvation and is believed to be responsible for ...