A study has identified a key disruption in cholesterol transport to the brain in patients with Alzheimer's disease. The ...

The role of lipids in the development of Alzheimer’s disease A European consortium coordinated by UNIGE shows how a mutation in the APOE protein changes the lipid transport in the brain and ...

Since the 1990s, scientists have known cholesterol is important in Alzheimer's, but they gained little traction in their efforts to understand the relationship between the lipid and the disease.

Subcellular lipid composition and transport significantly influence the physiological and pathological functions of both ...

The researchers are currently studying how apoE’s transport of cholesterol and maintenance of lipid rafts in the brain impacts not only Aβ production but also brain inflammation.

Having confirmed that the E4 variant of the APOE gene promotes abnormal cholesterol accumulation in oligodendrocytes and decreases myelination, Tsai et al. sought to determine how these findings ...

Notably, these monocytes expressed ever-higher levels of lipid transport genes with age, including the AD risk genes ApoE and ApoC1, as well as phospholipid transfer protein, which regulates lipid ...

Some of the mice had their APOE genes removed and replaced with human APOE genes—some with APO3, which has an average risk of Alzheimer's, and APOE4, which doubles or even triples the risk.

Hansen and his laboratory are currently studying how apoE’s transport of cholesterol and maintenance of lipid rafts in the brain impacts not only Aβ production but also brain inflammation ...

Seeing APOE in real-time APOE is produced by astrocytes. Much like a taxi or Uber, the protein oversees the releasing and transporting lipids between cell types in the brain. Windham and Cohen ...