A study identified a novel APOE4-specific receptor LilrB3. A butterfly-like Cryo-EM structure of the complex reveals the details of how the immune “checkpoint” receptor LilrB3 recognizes APOE4.

NEW YORK, April 21 (Reuters) - APOE4 is the strongest risk factor for late-onset Alzheimer's, the most common form of the disease that develops after the age of 65, according to the National ...

In this new study, the research team has found evidence suggesting that AD due to homozygous APOE4 genes should be classified as a third general type of the disease, rather than as a risk factor.

For more than 30 years, Alzheimer’s researchers have thought of APOE4 as a major genetic risk factor for most cases of the devastating neurologic disease. But a new study published on Monday ...

Using mouse models with a humanized APOE4 gene, USC researchers uncover the sequence of early molecular changes caused by APOE4, a discovery which may help identify potential treatment targets in ...

Non-APOE4 carriers do not benefit from treatment with lecanemab. Lecanemab reduces the rate of progression of APOE4 carriers closer to that of non-carriers in mild Alzheimer's disease. While rare ...

Topline results were announced from a phase 3 trial evaluating valiltramiprosate (ALZ-801) in apolipoprotein ε4 allele (APOE4) carriers with early Alzheimer disease (AD). Valiltramiprosate is an ...

In a recent study published in the journal Scientific Reports, researchers compare the impact of apolipoprotein E ε4 (APOE4) levels on mortality risk. APOE4 is a well-known genetic risk factor ...

Scientists have long known a gene called APOE4 is one of many things that can increase people’s risk for Alzheimer's, including simply getting older. The vast majority of Alzheimer’s cases ...

People with two copies of the gene variant APOE4 are almost certain to get Alzheimer’s, say researchers, who proposed a framework under which such patients could be diagnosed years before symptoms.

The study, published today in Nature Medicine, also concludes that those individuals homozygous for APOE4 also develop the disease earlier than those with other variants of the APOE gene.