By simplifying ketone transformation ... only two specific sites within their structure—the carbonyl carbon and the alpha position—are easily accessible to conventional chemical reactions.

Trimerization of commercially available coprostanone (a steroid ketone with a cis A/B ring junction) by treatment with titanium tetrachloride yields this unusual, chiral, cleft-containing molecule.

elegans, reveal the ketone body β-hydroxybutyrate interacts directly with misfolded proteins, altering their solubility and structure so they can be cleared from the brain through the process of ...