Ketamine is an antagonist of the NMDA receptor. That means it keeps things like glutamate from activating the NMDA receptor. When ketamine occupies the receptor, you start to feel sleepy ...

Ketamine affects several receptors and pathways in the brain and body, with one key pathway involving glutamate. As an NMDA receptor antagonist, ketamine blocks glutamate from binding to NMDA ...

Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a promising treatment for TRD. Originally an anesthetic, ketamine has shown rapid antidepressant effects ...

Pharmacology and Neurobiological Mechanisms of Action Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a promising treatment for TRD. Originally an ...

Preclinical data supports the advancement of oral Ketamir-2 as a safe, next-generation alternative to ketamine ... a known neurotoxic NMDA receptor antagonist. Brain tissues were examined through ...

But doctors do use one NMDA receptor antagonist: memantine (Namenda XR). It's been approved in the U.S. and Europe as a treatment for Alzheimer's disease. It's typically used when a person has ...