Ketamine is an antagonist of the NMDA receptor. That means it keeps things like glutamate from activating the NMDA receptor. When ketamine occupies the receptor, you start to feel sleepy ...

Ketamine affects several receptors and pathways in the brain and body, with one key pathway involving glutamate. As an NMDA receptor antagonist, ketamine blocks glutamate from binding to NMDA ...

Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a promising treatment for TRD. Originally an anesthetic, ketamine has shown rapid antidepressant effects ...

Preclinical data supports the advancement of oral Ketamir-2 as a safe, next-generation alternative to ketamine ... its novel oral NMDA receptor antagonist. The study was required by the U.S ...

But doctors do use one NMDA receptor antagonist: memantine (Namenda XR). It's been approved in the U.S. and Europe as a treatment for Alzheimer's disease. It's typically used when a person has ...

Ketamine has received a Hollywood makeover. It used to be known as a rave drug (street name special K) and cat anesthetic. However, in recent years, some doctors have prescribed ketamine to treat ...