A Cleveland Clinic psychiatrist explains how ketamine therapy is transforming depression treatment—and why it works when ...

Recent research shows that the mechanism of action of ketamine is complicated but involves the opioid receptors of the brain. Maybe this is a reason why ketamine can be addictive?

New research published in the Journal of Psychopharmacology has found that a single dose of psilocybin leads to widespread ...

Note that ketamine is remarkable because of its unique mechanism, rapidity of action, antisuicidal effects, and ability to treat depressed patients for whom every other treatment has failed.

Pharmacology and Neurobiological Mechanisms of Action Ketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a promising treatment for TRD.

A single dose of ketamine, when paired with a compound like BCI, could potentially offer relief for up to two months. That’s a huge leap from the current window of just a few days.

Vanderbilt University. "New ketamine study promises extended relief for depression." ScienceDaily. ScienceDaily, 22 May 2025. <www.sciencedaily.com / releases / 2025 / 05 / 250522183206.htm>.