Adrenomedullin disrupts insulin signaling in blood vessels, leading to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study by a team at the Max Planck ...

Insulin resistance is a hallmark of multiple metabolic disorders, including type 2 diabetes, obesity, metabolic syndrome, and polycystic ovary syndrome. It ...

In conclusion, we have shown that insulin signaling and EPC survival are impaired in Zucker fatty insulin-resistant rats. This defect can be ameliorated significantly by a knockdown of RelA ...

In the liver, the insulin-signaling cascade branches downstream of its receptor to form one pathway that suppresses gluconeogenesis and another pathway that activates de novo lipogenesis (Figure 3).

Investigators at the Helmholtz Institute have shown that inceptor, an inhibitor of the insulin signaling pathway, acted by binding insulin and targeting it for degradation. “Insulin was discovered 100 ...

Protein tyrosine phosphatase receptor type J (PTPRJ) is a negative regulator of insulin signaling in neuronal cells, according to a new study, and appears to have a role in nervous system ...

Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...

The paper in Cell Metabolism may transform our understanding of how obesity-induced insulin resistance develops and how to treat it. "We have been interested in the basic mechanisms of how obesity ...