The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study.

“There’s been several data sets about trying to treat the insulin pathway or use the insulin pathway as somehow a benefit to ...

Thus, neuronal insulin-like signaling appears to be a key regulator of various essential functions in C. elegans, and the metabolic and reproductive defects induced by whole-body deletion of DAF-2 ...

Insulin is a vital hormone that controls numerous ... such as in the so-called mTOR signaling pathway—a key regulator of cell ...

Type 2 diabetes mellitus (T2DM) is a complex disorder that has a heterogeneous genetic and environmental background. In this Review, we discuss the role of relatively infrequent polymorphisms of ...

The study explores whether Prolia/Xgeva (denosumab), a widely used therapy for osteoporosis and bone tumors, can regenerate ...

New research identifies the liver protein PTPRD as a key regulator of metabolic liver disease. Reduced levels of PTPRD disrupt glucose and lipid metabolism, promote liver fat accumulation, and impair ...

A study in Nutrients finds regular mango intake boosts insulin sensitivity and fights inflammation in overweight or obese adults.

Several lines of evidence link metabolic dysregulation to late-life neurodegenerative diseases. The altered glucose ...

Researchers have discovered a novel approach to protecting insulin-producing beta cells from the damaging effects of glucolipotoxicity - a harmful condition linked to the progression of type 2 ...

City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the United States and a ...