Medical Xpress27d
Melanoma metastasis: Research unveils the cell death pathway in bone
This discovery provides a new therapeutic target and offers hope for improving the management of bone metastases in melanoma patients. The researchers used both in vivo and in vitro models to ...
Nature13y
A novel role for CCL3 (MIP-1α) in myeloma-induced bone disease via osteocalcin downregulation and inhibition of osteoblast function
OCN expression in vitro and in vivo. These data therefore suggest that the pro-inflammatory chemokine CCL3 may contribute to OB/OC uncoupling characteristic of MM bone disease, prompting the ...
Medical Xpress on MSN8d
Scientists develop realistic 'micro-gut' model to study relationship between gut microbes and human diseases
In a breakthrough for the advanced study of gut health, NUS scientists have developed a 3D microscopic version of the human ...
The Scientist1y
Exploring Preclinical Models for Inflammatory Bowel Disease
These models include humanized stem cell-derived in vitro systems that recreate the epithelial cell ... the luminal and basal sides of the epithelial cell monolayer. Unlike 3D model systems, ...
Armed robbery in Revesby8d
Protein Inhibitor Eases Cartilage Damage in Arthritis Model
Protein disulfide isomerases (PDIs) are essential enzymes that facilitate the proper folding of proteins and maintain protein quality within the ...