A well-known in vitro model of the blood-brain barrier that is widely used in studies of neurodegenerative diseases and in preclinical research is made from the wrong kind of cells, according to ...

In contrast, blood vessel organoids did not express these molecules before integrating into the cerebral organoids. To assess the barrier ... brain,” he said. This is particularly important since ...

Researchers at the National University of Singapore have reported crossing the blood–brain barrier with help from a modified Lactobacillus plantarum. By delivering an appetite-regulating hormone ...

A 3D model accurately mimicking the Blood-Brain Barrier (BBB) in a laboratory environment has been successfully developed by research teams led by Professor Jinah Jang from the Departments of ...

For decades, scientists across the globe have investigated methods to accurately measure drug permeability across the ...

A 3D model accurately mimicking the Blood-Brain Barrier (BBB) in a laboratory environment has been successfully developed by research teams led by Professor Jinah Jang from the Departments of ...

In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...

glial cells and the blood-brain barrier following ischemic insult. We also describe the evidence of TRPM2 involvement in these processes, as shown from numerous in vitro and in vivo studies that ...

Rasagiline is rapidly absorbed by the gastrointestinal tract and readily crosses the blood-brain barrier. The optimal ... in experimental laboratory models. The mechanisms whereby rasagiline ...

Chronic neuroinflammation is due to BBB dysfunction disrupting brain blood vessel and nerve cell interactions. However, existing BBB models have been unable to replicate the complex three ...