Our body is made up of millions of cells that coordinate daily function. They are constantly working to maintain activity and ...

To understand how DJ-1 hydrolyzes cyclic 3-phosphoglyceric anhydride—a highly reactive, toxic cellular metabolite—researchers ...

A mutant DJ-1 gene causes recessive Parkinson's disease, but the molecular mechanism of this process has not been well ...

Additionally, an alternative metabolism called glycolysis, which is able to produce energy in human cells when no oxygen is present, is similarly known to be required for IFN-γ induction in T cells.

As a result, glucose metabolism is rerouted towards aerobic glycolysis, boosting lactate production. The elevated lactate levels then induce histone lactylation, especially at H3K56, triggering ...

STAT3 dephosphorylation inhibits the cellular cycle, stimulating apoptotic pathways via NF-κB and p38 MAPK activation. Various cell-signaling mechanisms mediated the extract's inhibitory effects.

As a result, glucose metabolism is rerouted towards aerobic glycolysis, boosting lactate production. The elevated lactate levels then induce histone lactylation, especially at H3K56, triggering ...