SEC foes Auburn and Florida will meet in the early game with Big 12 Champion Houston and Duke, the ACC Champ, tangling in the nightcap. Houston is making their seventh appearance in the Final Four but still seeking their first national title.

It’s the Duke Blue Devils vs Houston in the Final Four of the March Madness bracket. Here’s our prediction, pick for the 2025 NCAA Tournament game.

The University of Houston is entering the Final Four as a betting underdog and you won’t get much of a differing opinion from the college basketball experts on TV. ESPN’s Steve Coughlin, aka “Stanford Steve”,