"This trial is the culmination of 25 years of clinical research at NIDCR to understand the underlying mechanisms of fibrous dysplasia and to identify promising treatments," said NIDCR Director ...

Fibrous dysplasia is a rare, mosaic disorder that leads to fractures, pain, and disability. Gain-of-function GNAS variants alter skeletal stem-cell differentiation, which results in the formation ...

According to the AAOS, around 7% of all benign bone tumors are fibrous dysplasia. People with fibrous dysplasia will experience abnormal fibrous tissue growth in the place of normal bone.

Ectodermal dysplasia: The different types of ectodermal dysplasia affect the hair, teeth, nails, skin, and sweat glands in different ways. Symptoms can include brittle hair, abnormal teeth ...

Emanuel has polyostotic fibrous dysplasia, a rare bone disorder where scar-like tissue forms instead of bones. Sometimes large tumors, which are benign, develop, too.