Fibrous dysplasia is a rare, mosaic disorder that leads to fractures, pain, and disability. Gain-of-function GNAS variants alter skeletal stem-cell differentiation, which results in the formation ...

More information: Luis F. de Castro et al, Safety and Efficacy of Denosumab for Fibrous Dysplasia of Bone, New England Journal of Medicine (2023). DOI: 10.1056/NEJMc2214862 ...

Fibrous dysplasia is a rare congenital disease of the bone that often affects the cranial facial structures, Dr. Netanel Ben-Shalom, a nuerosurgeon, at Northwell Lenox Hill Hospital, tells TODAY.com.