The researchers propose that interacting with the ER-alpha-Clic1 complex enables estrogen to trigger fast neuronal responses through Clic1 ion currents. The study appeared in Science Advances.

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects ...

Estrogen plays an important role in keeping bones healthy. Now, researchers investigated how membrane-initiated estrogen receptor alpha (mERα) signaling in specific cell types of female mice affects ...

Subsequently, nine peptide sequences (SP 1 to 9) were extracted, and their effects on human estrogen receptor alpha (ERα)-mediated transcriptional activation were assessed.

Cherubini, A., Ostadreza, M., Jamialahmadi, O. et al. Interaction between estrogen receptor-α and PNPLA3 p.I148M variant drives fatty liver disease susceptibility in women.

Abstract 529 Background: Neoadjuvant chemotherapy (NAC) is commonly administered to patients (pts) with estrogen receptor alpha (ER) negative (immunohistochemistry [IHC] 0%) and ER-low (IHC 1-10%) ...

A total of 624 patients underwent randomization; 313 were assigned to receive vepdegestrant, and 311 to receive fulvestrant. Among the 270 patients with ESR1 mutations, the median progression-free ...

An estrogen-sensitive hypothalamus-midbrain neural circuit controls thermogenesis and physical activity. Science Advances, 2022; 8 (3) DOI: 10.1126/sciadv.abk0185 ...