Pathway analysis revealed RAS signaling and inflammation were enriched in BRAF V600E compared to WT in both HGG and LGG (NES > 2; FDR < 0.005), regardless of age. When comparing all V600E HGG patients ...

Background: Mitogen-activated protein kinase (MAPK) pathway is a key regulator of cellular proliferation and survival, it is highly correlated with the occurrence of many cancers, JSI-1187 is a potent ...