Explore how cutting-edge agents like alpelisib, capivasertib, MEK and ERK inhibitors, and JAK inhibitors are reshaping the ...

We showed that atypical chemokine receptor CXCR7 is up-regulated following AR-targeted therapies, activating MAPK/ERK signaling and resulting in treatment resistance (Li et al., Cancer Res. 2019). To ...

Since ERK activation is an important signaling pathway associated with many physiological functions, targeting this can offer new research strategies for GPCR-based drug discovery. In specific ...

Exploration of extending ketamine’s antidepressant effects by enhancing intracellular signaling pathways in major depressive ...

The quality of a cell signal, not just its strength, can determine whether a cell will follow a path toward cancer. This finding, which emerged from optogenetic interrogations of both healthy ...

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

Researchers are shining light on new stages of the ERK pathway. Researchers at the ... While their previous work focused on aspects of the signaling pathway from the liver to the pancreas, this ...

Perturbation of protein kinase signaling by mutations and other genetic alterations ... the most characterized MAP kinase pathway is the raf-MEK-ERK pathway. Given its significant implications in ...

The signaling pathway is initiated by ligand binding to ... including activation of several MAP kinase kinase (MKKs) and MAPK/ERK Kinase (MEKs) pathways. Due to the crucial role TGF-β signaling ...