Ubiquitin is a small, covalent modifier that forms a poly-ubiquitin chain on protein, which becomes a degradation signal attacked by the 26S proteasome 11,12,13. The poly-ubiquitin chain is ...
Expert Rev Proteomics. 2010;7(4):519-542. PARK2/PARKIN PARK2 is characterized by genetic defects in the parkin protein, an E3 ubiquitin ligase that targets misfolded proteins to the UPS.
Our most recent work is focused on elucidating how a protein kinase (PINK1) controls the activity of a ubiquitin E3 ligase (Parkin) to specify cell fate decisions. Mutations in genes encoding for ...
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