The work points toward dozens of genes that connect cell stress and diabetes risk, including one that is already under investigation as a drug target for type 2 diabetes complications.

Reversing mitochondrial damage could help cure diabetes Regardless of the cell type, the researchers found that damage to the mitochondria did not cause cell death.

This editorial was published on June 22, 2025, and updated on July 10, 2025, at NEJM.org.

It found the pill lowered A1C, a blood level used to diagnose diabetes, by an average of 1.3% to 1.6%, across different doses, after 40 weeks. Participants taking the highest dose also lost an ...

Conclusions Once-weekly cagrilintide–semaglutide (at a dose of 2.4 mg each) resulted in a significantly lower body weight than placebo in adults with obesity and type 2 diabetes.