Depression, or major depressive disorder, is a mental health condition marked by an overwhelming feeling of sadness, isolation and despair that affects how a person thinks, feels and functions.

"There are clearly many shades of major depression. … There is no 'one-size-fits-all' solution. Rather, the best clinical intervention for the person with [treatment-resistant depression] should ...

“There’s a major sense of loss to the person’s body and to their psyche,” Thisler said. For people that have a history of depression, being diagnosed with a chronic illness can be ...