News Medical on MSN6d
Opioid δ-receptor agonists show promise for treating IBS-like symptoms
Research reveals that δ-receptor agonists like KNT-127 alleviate IBS symptoms by modulating gut-brain interactions and ...
News Medical1mon
Uncovering the neurobiological mechanisms of delta opioid receptor agonists
The delta opioid receptor (DOP) plays a key role in mood regulation, making it a promising target for therapeutic intervention. Studies have shown that selective DOP agonists (compounds that ...
EurekAlert!9d
Beyond the gut: A new frontier in IBS treatment by targeting the brain
Irritable bowel syndrome (IBS) is a common digestive disorder with unclear causes, affecting about 10% of the global ...
Your IBS May Be a Brain Problem – And Researchers Have the Answer
A groundbreaking study suggests that IBS might be more of a brain issue than a gut disorder. Researchers found that ...
Nature3y
Opioids and Their Complicated Receptor Complexes
1973; Terenius 1973). Subsequent pharmacological studies using different ligands uncovered three opioid receptor types, kappa, delta and mu (Chang and Cuatrecasas 1979; Lord et al. 1977 ...
EurekAlert!8d
Overview of the study: Opioid delta-receptor agonists alleviate stress-induced IBS symptoms via the insular cortex (IMAGE)
Using an innovative and recently validated animal model of IBS, the researchers showed that opioid delta-receptor agonists ...
Medical Xpress1mon
Scientists uncover rapid-acting, low-side-effect antidepressant target
The delta opioid receptor (DOP) plays a key role in mood regulation, making it a promising target for therapeutic intervention. Studies have shown that selective DOP agonists (compounds that ...
Science Daily1mon
Scientists uncover rapid-acting, low-side-effect antidepressant target
Researchers have previously demonstrated antidepressant-like effects of delta opioid receptor agonists in rodents. In their latest study, they uncover the molecular and cellular mechanism ...