Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...

More information: Xing Kang et al, Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors, Cell (2025). DOI: 10.1016/j.cell.2025.04.012 Provided by Chinese ...

Research on mitochondrial DNA (mtDNA) reveals that the mitochondrial transcription elongation factor (TEFM) is crucial for maintaining the balance between mtDNA transcription and replication.

A joint study revealing a new mechanism on DNA Replication Initiation, led by The University of Hong Kong (HKU), The Hong Kong University of Science and Technology (HKUST), and other institutions ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding, published ...

When these pathways are activated, DNA replication is suppressed at sites in the genome called origins; at the same time, the progression of DNA replication forks also slows down. Replication forks, ...

The G4-DNA structure can therefore be involved in both the enhanced and impairment of transcription in active neurons, based on their activity, to enable different memory states.

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer.

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for ...

When these pathways are activated, DNA replication is suppressed at sites in the genome called origins; at the same time, the progression of DNA replication forks also slows down. Replication forks, ...