The accuracy of these copies determines the health and inherited features of the nascent cells, so it is essential that the process of DNA replication be as accurate as possible (Figure 1).

as replication fork proteins can collide with them and become displaced from DNA. These include various DNA binding proteins such as the transcription machinery. Another physical barrier could be ...

Scientists have identified a key vulnerability in pancreatic cancer by targeting transcription-replication conflicts—cellular ...

Understanding the process of replication and transcription of mtDNA is crucial ... "While mtDNA is much smaller than nuclear ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

Researchers have identified a new molecular target for treating pancreatic cancer. Scientists focused on transcription-replication conflicts (TRCs), which occur when the mechanisms responsible for ...

chemistry professor Floyd Romesberg of the Scripps Research Institute in California and colleagues extended this alphabet, reporting the creation of additional artificial nucleotides, X and Y, that ...

The complementary nature of base pairing allows for the accurate replication of DNA during cell division and the transcription of DNA into RNA for protein synthesis.

The process is made up of the transcription and translation of DNA sequences. Genome and mutations DNA replication is carefully controlled to preserve the genetic information. However, changes in ...

Epub 2025 Mar 7. Looping out of control: R-loops in transcription-replication conflict. Kumar C, Remus D. Chromosoma. 2024. 133(1):37-56. Doi: 10.1007/s00412-023-00804-8. PMCID: PMC10771546. Multistep ...

This strong base pairing is crucial for the stability of the DNA double helix and the accurate replication and transcription of genetic information. The specific pattern of hydrogen bonding between ...