During circular DNA replication, the excised primer is readily replaced by nucleotides, leaving no gap in the newly synthesized DNA. In contrast, in linear DNA replication, there is always a small ...

replicons use bacterial RNAP to synthesize a replication primer. The mechanism(s) that ensure the transfer of the primer's 3′ end, which must be annealed to the template DNA, from RNAP to DNAP ...

An enzyme called primase attaches a “primer” to each strand that allows replication to start, then another enzyme called DNA polymerase attaches at the primer and moves along the strand adding new ...

An enzyme called primase attaches a "primer" to each strand that allows replication to start, then another enzyme called DNA polymerase attaches at the primer and moves along the strand adding new ...

In this process, regions downstream the RNA primer are removed resulting in RNA-to-DNA transition sites being separated from the ligation point of the H strand at the end of replication.

These enzymes are essential to DNA replication and usually work in pairs ... only add nucleotides to a pre-existing 3'-OH group. A primer is therefore needed, at which nucleotides can be added.

The enzyme itself could not bypass template damage in a primer-extension assay. These findings suggest that DNA damage at the replication fork can be replicated directly by the replisome without the ...

Then a third enzyme, "polymerase," joins the party by attaching to the primer, moving along with the growing strand and adding new letters to form another double helix. In DNA replication ...

All of the proteins involved in DNA replication rely on metal ions -- either magnesium ... and a thumb domain that binds the primer/template DNA,” he said. But until now, scientists could only guess ...

The average dividing cell must copy—perfectly—3.2 billion base pairs of DNA, about once every 24 hours. The cell’s replication machinery does an amazing job of this, copying genetic material ...

A new discovery by researchers at the RIKEN Center for Biosystems Dynamics (BDR) in Japan upends decades of assumptions regarding DNA replication. Led by Ichiro Hiratani and colleagues ...