Using cryo-microscopy, researchers present a high-resolution structure of monkeypox virus DNA polymerase holoenzyme, a complex that plays a key role in the genome replication process of the virus.

They determined the holoenzyme structure in complex with DNA using cryo-electron microscopy at the global resolution of ~2.8 Å. According to the findings, the holoenzyme possesses an architecture ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, No. 4 (January 24, 2017), pp. 675-680 (6 pages) The eukaryotic genome is primarily replicated by two DNA ...

In bacterial cells, DNA polymerase III is known to make about 2,000 of these mistakes every time it copies a cell’s genetic material. To maintain genome integrity, the bulk of misplaced ...

In bacterial cells, DNA polymerase III is known to make about 2,000 of these mistakes every time it copies a cell's genetic material.

The DNA polymerase III holoenzyme, which carries out chromosomal DNA replication in Escherichia coli, comprises three main parts: the catalytic core, responsible for DNA synthesis; the doughnut ...

RNA polymerase (Pol) III has a noncanonical role of viral DNA sensing in the innate immune system. This polymerase transcribes viral genomes to produce RNAs that lead to induction of type I ...

How Herpes’ DNA Polymerase Helps Virus Evade Antiviral Drugs August 28, 2024 Herpes virus [photoman / 1173676633 / iStock / Getty Images Plus] ...

Researchers reveal DNA repair mechanism Date: May 21, 2023 Source: NYU Langone Health / NYU Grossman School of Medicine Summary: A new study adds to an emerging, radically new picture of how ...