Investigating chromatin's 3D architecture reveals its influence on gene regulation, shedding light on mechanisms underlying cancer and muscular dystrophy.

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot.

Newly developed DNA nanostructures can form flexible, fluid, and stimuli-responsive condensates without relying on chemical ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the mechanism by which cells identify and repair a highly toxic form of DNA ...

If DNA bridges persist between chromosomes during cell division, chromosomes are abnormally segregated, leading to genetic instability and cancer. Researchers at UNIST and IBS have experimentally ...

Researchers at EPFL have discovered how the structure of DNA packaging in cells determines which proteins can interact with the key tumor suppressor p53.

Another protein, CTCF, attaches to locations of super-enhancer DNA and pairs them up with genes that they will later turn on during sperm development. This sets up a new structure that cements the ...

NIH/National Eye Institute. "3D map reveals DNA organization within human retina cells." ScienceDaily. ScienceDaily, 7 October 2022. <www.sciencedaily.com / releases / 2022 / 10 / 221007112116.htm>.

A transcription factor in immune cells forms an unexpectedly ladder-like complex with two DNA molecules, allowing the expression of genes that these cells need to suppress harmful immune responses ...