Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

Many major cancers, including those of the lung, breast and prostate gland, spread to the bones as they progress.

Many major cancers, including those of the lung, breast and prostate gland, spread to the bones as they progress. These bone ...

The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their ...

A paper published in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel ...

Recent advancements in dermatology have highlighted the crucial role of dermal T cell immunity in regulating hair follicle ...

Activated lymphocytes secrete high levels of interferon-γ, further activating macrophages, which in turn activate more T cells (Figure 1B). 7-10 This circle of immune activation can develop in ...

In cell culture assays, ApoE4 CD8+ T cells wriggled across a layer of brain endothelial cells more efficiently than did their E3 counterparts. In the brains of 6-month-old mice, Halters noticed that ...

The question isn’t new. In 2020, Tony Wyss-Coray and colleagues at Stanford University spotted clonally expanded CD8⁺ cytotoxic T cells in the cerebrospinal fluid and postmortem brains of people with ...