Mice with inducible reporter genes allow systemic profiling of gene expression throughout the brain. Researchers led by Hongkui Zeng at the Allen Brain Institute have created and characterized ...
Unlike many site-specific recombinases that require accessory proteins, the Cre recombinase itself organizes a synaptic complex to initiate the recombination reaction. A new study suggests how Cre ...
7monon MSN
One-step creation of Cre-loxP organisms: Precise control and modification of gene expression
Researchers at the University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA ...
To discover the function of a gene researchers turn it off and observe the consequences. Often genes have multiple functions that differ depending on a tissue and age. Some genes are essential to ...
“One limitation [of Cre-LoxP], the focus of this editorial, is the potential loss of fidelity of Cre recombinase expression especially in the context of modeling cancer in mice.” “It is based on ...
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