Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are sporadic four-repeat tauopathies that have characteristic clinical and neuropathologic profiles, but also share ...

The term corticobasal degeneration is reserved for autopsy-confirmed CBS. The cause of CBS is not yet known. Like other neurodegenerative diseases, patients with CBS accumulate misfolded proteins ...

For example, astrocytic tau pathology is associated with synaptic loss in corticobasal degeneration but not in progressive supranuclear palsy. Furthermore, changes that are more difficult and ...