Figure 1: Oral priming immunizations generate clonally related long-lived plasma cells in the gut lamina propria and bone marrow. Figure 2: Re-exposure to oral or systemic antigen after 1 year ...

Multiple myeloma is a malignant disease characterized by proliferation of clonal plasma cells in the bone marrow and typically accompanied by the secretion of monoclonal immunoglobulins that are ...

Plasma cell leukemia (PCL) is a rare disease that may present de novoor secondary to plasma cell myeloma. Advanced disease and extramedullary involvement are common clinical features at presentation.

They include: Greater than 10% of clonal bone marrow plasma cells on bone biopsy or extramedullary plasmacytoma Presence of one or more of the previous CRAB features or the following myeloma ...

Multiple myeloma (MM) is a bone marrow cancer caused by clonal proliferation of plasma cells, and it is classified as a plasma cell dyscrasia. Over the last 20 years, there has been a dramatic ...

First, clonal-mutation prevalence is a ... tumor DNA from these cells may be released into the bloodstream as plasma DNA. If circulating tumor DNA can be detected and sequenced, it can be used ...

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of immunoglobulins, also called antibodies. But in this disease, light chains misfold ...

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of ...

Clonal plasma cells in the bone marrow secrete free light chains into circulation. These light chains are part of immunoglobulins, also called antibodies. But in this disease, light chains misfold ...

Some of them become white blood cells, which are an important part of your body’s immune system. Plasma cells are a type of white blood cell. Normally, they make antibodies -- proteins to help ...

This composite flow cytometric panel illustrates the bone marrow of a newly diagnosed primary plasma cell leukemia patient demonstrating CD38 +, λ-a-restricted, CD20-plasma cells.