In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

Dr. David A. Braun delved into the molecular factors which drive exceptional responses to immunotherapy in metastatic clear cell renal cell carcinoma.

Study: Ongoing replication stress tolerance and clonal T cell responses distinguish ... profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma (PDAC).

Metastatic clear cell renal cell carcinoma ... patients with exceptional responses had a significantly higher total of clonal neoantigens, which are unique DNA changes present on all of the ...