In patients with RCC, exceptional response to immunotherapy may be related to clonal neoantigen-driven cytotoxic T-cell ...

Study: Ongoing replication stress tolerance and clonal T cell responses distinguish ... profiles that impact the prognosis of patients with metastatic pancreatic ductal adenocarcinoma (PDAC).

Dr. David A. Braun delved into the molecular factors which drive exceptional responses to immunotherapy in metastatic clear cell renal cell carcinoma.

Metastatic clear cell renal cell carcinoma ... patients with exceptional responses had a significantly higher total of clonal neoantigens, which are unique DNA changes present on all of the ...