Down syndrome, which causes a range of developmental differences and affects 1 in 700 newborns in the United States, is caused by the presence of an extra copy of chromosome 21.

Led by Ryotaro Hashizume at Mie University, the research team demonstrated that CRISPR can be used to remove the extra copy of chromosome 21 - the fundamental cause of Down syndrome ...

High p-tau217 and GFAP levels predicted future amyloid buildup. Down syndrome-related Alzheimer's disease is now considered a genetically determined form of Alzheimer's.

Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. Alzheimer's & Dementia, 2025; 21 (6) DOI: 10.1002/alz.70322 ...