Zyrtec (cetirizine) and Zyrtec-D (cetirizine and pseudoephedrine) have similar names and uses. However, the key difference between the medications is that, in addition to cetirizine, Zyrtec-D ...

Medically reviewed by Lindsay Cook, PharmD Xyzal (levocetirizine) and Zyrtec (cetirizine) are antihistamines taken to relieve allergy symptoms such as sneezing, runny nose, itchy eyes, and hives.