Most cell signals are chemical in nature. For example, prokaryotic organisms have sensors that detect nutrients and help them navigate toward food sources. In multicellular organisms, growth ...

How do these molecules activate signaling pathways in their target cells? They bind to cell-surface proteins of the seven-helix-G protein-coupled receptors (GPCRs). These in turn activate either ...

The technology called dFLASH (dual FLuorescent transcription factor Activity Sensor for Histone-integrated live-cell reporting ... that control signaling pathways of therapeutic interest.