Researchers discover short form of a tumor-produced protein activates natural killer cells
A group of scientists in China has revealed a novel mechanism whereby a short form of IL-18, generated by caspase-3 cleavage in tumor cells, activates natural killer (NK) cells to suppress tumor ...
EurekAlert!15d
Researchers discover anti-cancer potential of immune modulator's short form
Prof. MENG Guangxun's team from the Shanghai Institute of Immunity and Infection of the Chinese Academy of Sciences, and collaborators, have revealed a novel mechanism whereby a short form of IL-18, ...
Nature16d
Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule
Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains largely uncharacterized. We show here that Fas kills activated primary T cells ...