All patients tolerated a 2-week course of carvedilol 6.25mg twice daily ... death and total hospitalizations were reduced by about 25% over 18 to 24 months. In the 3 largest U.S. trials, death ...

They also showed that a low dose of carvedilol (e.g., <25 mg per day) is as effective as higher doses (e.g., 25–50 mg per day) at decreasing HVPG, with a lower risk of causing arterial hypotension.

Carvedilol has the capacity to block both the β-1 and β-2 adrenergic receptors, as well as the α-1 receptors. There is evidence to indicate that full adrenergic blockade by carvedilol improves ...

For example, lower doses of metoprolol CR/XL have not been demonstrated to be effective, whereas carvedilol reduces mortality and morbidity across the dose range from 6.25 25.0 mg b.i.d. [1 ...