The interactions between transcription factors guided by DNA are poorly understood. In a new study, researchers from the Sanger Institute and the University of Cambridge used two novel algorithms ...

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase ...

Taking a cue from nature, the researchers showed they could all but eliminate off-target gene activation by designing weak transcription factors that cooperatively assemble. Bioengineers can ...

Deep neural network predicts transcription factors A deep learning-based tool predicts transcription factors using protein sequences as inputs Date: January 5, 2021 Source: The Korea Advanced ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

The latest insights into transcription factors provide a deeper understanding of the disease's progression and potential therapeutic interventions. Transcription factors are critical proteins that ...

Flare Therapeutics has launched with $82 million in series A financing to discover small-molecule drugs that target transcription factors implicated in cancer. The life science venture capital ...

Transcription factors affect a cell’s transcription patterns, regulating gene expression. In the case of T cells, Peng’s research shows that the transcription factors Tcf1 and Lef1 activate ...

Michael Erb, a chemical biologist at Scripps Research and coauthor on the paper, tells C&EN that transcription factors were previously considered undruggable because they “don’t have the types ...

Rob Sims, Ph.D. (Flare Therapeutics) "This collaboration will accelerate the expansion of our capabilities, enabling us to develop treatments for transcription factors implicated in indications wi ...

The researchers' results reveal new patterns and preferences in how certain transcription factors interact with each other—also known as "motifs." In this study, the researchers estimate that ...