Pathogen-fighting immune cells called tissue-resident memory CD8 T cells (TRM cells) go through a surprising transformation -- and relocation -- as they fight infections in the small intestine.

Within the immune system, CD8 + T cells are the main defensive adaptive ... Mechanistically, the E3 ligase BFAR suppressed cytokine-induced JAK2 signaling by activating JAK2 deubiquitination ...

Study: GZMK-expressing CD8+ T cells promote recurrent airway inflammatory ... promote inflammation and tissue damage by releasing cytokines and cationic proteins. The pro-inflammatory role of ...

Certain CD4+ and CD8+ T cells have a marker on their ... which secrete pro-inflammatory cytokines; therefore, blocking T-cell reactivation can diminish the production of the cytokines promoting ...

Findings indicate that altering glucose metabolism in T cells boosts their therapeutic potential against melanoma, paving the way for improved immunotherapies.

Panelists discuss how switching therapies in patients with alopecia areata (AA) is often necessary when initial treatments fail, though it can create a cost burden, and how beyond updated guidelines, ...

Early data shows potent and selective CD8+ T cell activation without substantial ... to a modified immunomodulatory protein, such as a cytokine. Our candidate design is intended to enable our ...

Panelists discuss how the data from the BRAVE-AA1 and BRAVE-AA2 phase 3 trials demonstrated the safety and efficacy of baricitinib, leading to its FDA approval in 2022 as the first systemic treatment ...

Early data shows potent and selective CD8+ T cell activation without substantial ... to a modified immunomodulatory protein, such as a cytokine. Our candidate design is intended to enable our ...