Here we provide insight into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target, complement fragment C3b. FH interacted with ...

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CR1 is expressed on blood cells and microglia. As a receptor for the complement components C3b and C4b, CR1 helps regulate activation of the complement cascade and promotes phagocytosis of immune ...

SAN DIEGO — The investigational drug pegcetacoplan, a C3/C3b inhibitor ... are characterized by excessive deposits of the complement protein C3c; however, no treatments are available that ...

But would the approach also work in humans? To test this out, the researchers assessed levels of C1q and also C3b—an activated complement protein further down the cascade—in symptomatic and ...

AP activation, AP-driven C3b formation and deposition were inhibited ... that distinguishes itself from other FDA approved anti-complement drugs. These results from Phase I trial are consistent ...

In this cascade, complement is initiated via random hydrolysis of the C3 protein, leading to mass deposition of the C3b portion on the nanoparticle surface. C3b is a recognizable ligand for ...

The C-terminal is the complement binding domain, which can inhibit complement activation through the classical pathway and the bypass pathway by specifically binding to C3b and C4b, and thereby ...

Complement component 3, often called C3, is an essential protein of the immune system. This protein plays a vital role in the body’s innate immune system, providing: the first line of defense ...